N. American Ex Awards 2017

, Pressure BioSciences, Inc. (OTCQB: PBIO) specialises in creating a range of instruments and consumables designed to support the discovery and development of new and improved drugs, vaccines, and diagnostic tests for the prevention, cure, and control of diseases and disorders in humans, animals, and plants, as well as for the improvement of knowledge and understanding in these areas. We invited CEO and Founder Richard T. Schumacher, a successful biotech entrepreneur for over thirty years, to talk us through the firmand the revolutionary solutions it provides to the vital life sciences market. Best New Instrument for Sample Preparation 2017: Barocycler 2320EXTREME & Recognized Leader in the Life Sciences – USA Founded in 2004, Pressure BioSciences draws on over 12 years’ experience to provide a range of pioneering instrument systems solutions based on the use of cycled pressure. The firm is focused on the development and commercialization of a novel, enabling, platform technology called pressure cycling technology (PCT). PCT uses cycles of hydrostatic low and high pressure to control bio- molecular interactions. Central to the firm’s focus is the development and sale of PCT- based systems (instruments and consumables) to address the challenging problems inherent in biological sample preparation, a crucial laboratory step performed by thousands of scientists worldwide working in biological life sciences research. Sample preparation is a term that refers to a wide range of activities that precede most forms of scientific analysis. Sample preparation is often complex, time-consuming, and one of most error-prone (but crucial) steps of scientific research. It is a widely-used laboratory undertaking, the requirements of which drive a large and growing market, estimated currently at approximately $6 billion worldwide. PBI’s PCT systems can be used to exquisitely control the sample preparation process. Richard outlines the reasons why this innovative technology is so vital to sample preparation. “PCT is a patented, enabling technology platform that uses alternating cycles of hydrostatic pressure between ambient (14.5 psi) and ultra-high levels (up to 100,000 psi) to safely, conveniently and reproducibly control the actions of molecules in biological samples, e.g., the rupture (lysis) of cells and tissues from human, animal, plant, and microbial sources; the enhancement of cellular reactions; and the inactivation of pathogens. “This technology is unique to Pressure BioSciences, and provides research scientists around the world with a powerful, 21st Century laboratory method to break open cells to release DNA, proteins, lipids, and other “biomolecules” from those cells in a high quality manner. The study of these biomolecules will allow scientists to increase their understanding of the role that these biomolecules play in certain diseases and disorders, which ultimately should result in better healthcare worldwide.” Richard continued: “All cells have a pressure point at which they will break open and release their biomolecules. Once that pressure point is determined, our instrument can be programmed to go to that pressure level, and then to cycle pressure from that level to a lower level then back to the higher level. Using this program, scientists are able to break the cell in a very reproducible and safe manner, which results in the cell not being “over-broken” (potentially damaging the biomolecules that scientists need to study) or “under-broken” (potentially not releasing the biomolecules that scientists need to study). K This exquisite control of the lysis process compares very favourably to the competition, who often use mechanical or chemical lysis methods in which “one-size-fits-all” (the extraction process is not easily tailored to the lysis of the cell; thus, over or under extracting the biomolecules from the cell can result).” Richard concluded: “Consequently, we are very excited, as are the scientists in our expanding customer base, with the recently released, next-generation Barocycler 2320EXTREME. This instrument includes a number of new features and benefits that offer the researcher the ability to go well beyond where they have gone with our previous version. Because the previous version was such a big seller for us, and was so well received by the life sciences research community, we believe that the new 2320EXT holds the potential for significant growth in 2017 and beyond.” PBI’s PCT-based instrument systems are currently used by